产品编号：C365703

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	C365703
名称:	N-​[Chloro(4-​nitrophenoxy)​phosphinyl]​-L-​alanine 1-​Methylethyl Ester
CAS号:	1809817-93-3
分子式:	C₁₂H₁₆ClN₂O₆P
分子量:	350.69
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N-​[Chloro(4-​nitrophenoxy)​phosphinyl]​-L-​alanine 1-​Methylethyl Ester is an intermediate in synthesizing PSI-7977-D5 (P839643), an isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
参考文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)