产品编号：C292100
产品规格：5mg
产品价格：面议
| 标准品编号: | C292100 |
| 名称: | CHIR-98014 |
| 别名: | N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro- 2,6-pyridinediamine; |
| CAS号: | 556813-39-9 |
| 分子式: | C₂₀H₁₇Cl₂N₉O₂ |
| 外观: | Yellow Solid |
| 熔点: | 192-196°C (dec.) |
| 分子量: | 486.31 |
| 储存: | 冰箱保存 |
| 溶解度: | DMSO, Methanol |
| 类别: | Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder. |
| 危险品信息: | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package |
| 参考文献 | |
