产品编号：C051500
产品规格：50mg
产品价格：面议
| 标准品编号: | C051500 |
| 名称: | Cabozantinib L-Malate Salt |
| 别名: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; XL 184; |
| CAS号: | 1140909-48-3 |
| 参考CAS: | 849217-68-1-free base |
| 分子式: | C₃₂H₃₀FN₃O₁₀ |
| 外观: | 白色至白色固体 |
| 熔点: | 166-169°C |
| 分子量: | 635.59 |
| 储存: | 冰箱保存 |
| 溶解度: | DMSO (Slightly), Methanol (Slightly, Heated) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. |
| 参考文献 | |
