产品编号：B448530

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	B448530
名称:	Bisindolylmaleimide XI Hydrochloride
别名:	3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride; Ro 31-0432;
CAS号:	145333-02-4
参考CAS:	131848-98-1
分子式:	C₂₈H₂₉ClN₄O₂
分子量:	489.01
类别:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
文献	Wilkinson, S.E. et al.: Biochem. J., 294, 335 (1993); Liu, Q., Chen, X. et al.: . Circ. Res. 105, 194 (2009); Birchall, A.M. et al.: J. Pharmacol. Exp. Ther., 268, 922 (1994);