产品编号：B443810

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	B443810
名称:	(E,E)-Bis(2-hydroxybenzylidene)acetone(2-HBA)
别名:	(1E,4E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one; 2-HBA; (E,E)-1,5-Bis(2-hydroxyphenyl)-1,4-pentadien-3-one;
CAS号:	131359-24-5
分子式:	C₁₇H₁₄O₃
分子量:	266.29
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.
文献	Perjesi, P. et al.: In Vivo, 20, 141 (2006); Magesh, S. et al.: Med. Res. Rev., 32, 687 (2012); Dinkova-Kostova, A.T. et al.: Cancer Lett., 245, 341 (2007);