产品编号：B433715

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	B433715
名称:	2-({[2-(4-Ethoxy-3-methoxyphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)pyrimidine-4,6-diamine
CAS号:	1209784-87-1
分子式:	C₁₇H₁₉N₅O₂S₂
分子量:	389.49
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2-({[2-(4-ethoxy-3-methoxyphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)pyrimidine-4,6-diamine, can be used in development of new deoxycytidine kinase (dCK) inhibitors. studies have shown that combined inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK) in multiple cancer cell lines depletes deoxycytidine triphosphate pools leading to DNA replication stress, cell cycle arrest, and apoptosis.
文献	Murphy, J. et al.: J. Med. Chem., vol. 56, Issue17, P: 6696-6708 (2013);