产品编号：B118790

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	B118790
名称:	BAY 11-7082
别名:	(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-(p-Tolylsulfonyl)-acrylonitrile; BAY 11-7821; BAY 117821
CAS号:	19542-67-7
分子式:	C₁₀H₉NO₂S
外观：	白色固体
熔点:	129-131°C
分子量:	207.25
储存:	Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度:	Chloroform (Slightly), Methanol (Slightly)
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of Iκβα without affecting constitutive Iκβα phosphorylation.
文献	Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)