产品编号：A795320

产品规格：250mg

产品价格：面议

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产品详情

标准品编号:	A795320
名称:	(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide
别名:	5,6,7,8-Tetrahydro-naphthalene-1-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide;
CAS号:	135729-78-1
分子式:	C₁₈H₂₄N₂O
外观:	白色固体
熔点:	157-159ºC
分子量:	284.4
储存:	冰箱保存
溶解度:	Chloroform (Slightly), Methanol (Slightly)
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide is an impurity in the synthesis of Palonosetron HCl (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
文献	Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

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