产品编号：A648350

产品规格：2mg

产品价格：面议

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产品详情

标准品编号:	A648350
名称:	2,5-Anhydro-2,5-imino-D-mannitol
别名:	2R,5R-Bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine; (2R,3R,4R,5R)-3,4-Dihydroxy-2,5-pyrrolidinedimethanol;
CAS号:	59920-31-9
分子式:	C₆H₁₃NO₄
外观:	白色至淡黄色固体
熔点:	114-117ËšC
分子量:	163.17
储存:	冰箱保存
溶解度:	Methanol (Slightly), Water (Slightly)
类别:	Research Tools; Enzyme Activators and Inhibitors; Glycosidase Inhibitors; Carbohydrates and Oligosaccharides;
应用:	Many pyrrolidines are powerful inhibitors of glycohydrolases, enzymes responsible for cleavage of glycosidic bonds, glycoprotein processing and the gastrointestinal breakdown of dietary carbohydrates. These compounds are charged at physiological pH and are believed to associate with acidic amino acids at the active site. Inhibition of glycohydrolases could be of therapeutic value for the treatment of viral infections, cancer, diabetes, and obesity.
文献	Fellows, L.E., et al.: J. Chem. Brit., 287, (1987), Elbein, A.D.: Annu. Rev. Biochem., 56, 497 (1987), Fleet, G.W., et al.: J. Chem. Brit., 287, (1989) Baxter, E.W., et al.: J. Org. Chem., 59, 3175 (1994); Tyms, A.S. et al. Lancet 1025, (1987); Spearman, M.A. et al. Expt. Cell Res. 168, 116 (1987); Horii, S. et al. J. Med. Chem. 29, 1038 (1986), Minami, Y., et al.: Bioorg. Med. Chem., 16, 2734 (2008),