产品编号：A634440
产品规格：
产品价格：面议
| 标准品编号: | A634440 |
| 名称: | (1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol |
| 别名: | Abacavir EP Impurity D |
| 杂质: | Abacavir EP Impurity D |
| CAS号: | 783292-37-5 |
| 分子式: | C₁₄H₁₈N₆O |
| 分子量: | 286.33 |
| 类别: | Research Tools; Molecular Biology; Enzyme Activators and Inhibitors; |
| 应用: | (1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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