产品编号：A603795
产品规格：50mg
产品价格：面议
| 标准品编号: | A603795 |
| 名称: | (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol |
| 别名: | Abacavir Impurity E; Abacavir Impurities; Abacavir EP Impurity E |
| 杂质: | Abacavir EP Impurity E |
| CAS号: | 208762-35-0 |
| 分子式: | C₁₄H₂₀N₆O |
| 状态： | 白色固体 |
| 熔点： | >80°C (dec.) |
| 分子量: | 288.35 |
| 储存： | -20°C Freezer |
| 溶解性: | Methanol (Slightly), Water (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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