产品编号：A105035
产品规格：25mg
产品价格：面议
| 标准品编号: | A105035 |
| 名称: | Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine |
| 别名: | N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; ; Abacavir Impurities;Abacavir EP Impurity B / USP - D |
| 杂质: | Abacavir EP Impurity B |
| CAS号: | 1443421-69-9 |
| 分子式: | C₁₈H₂₁ClN₁₀O |
| 分子量: | 428.88 |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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