产品编号：A105030
产品规格：10mg
产品价格：面议
| 标准品编号: | A105030 |
| 名称: | Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester |
| 分子式: | C₃₃H₄₆N₆O₁₀ |
| 状态： | 白色固体 |
| 分子量: | 686.75 |
| 溶解性: | Chloroform, Dichloromethane, DMSO, Methanol |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Abacavir 5’-(2,3,4-Tri-O-isobytyryl)-β-D-glucuronic Acid Methyl Ester is an intermediate used in the synthesis of various Abacavir metabolites. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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