产品编号：A105020
产品规格：2mg
产品价格：面议
| 标准品编号: | A105020 |
| 名称: | Abacavir 5’-Phosphate |
| 别名: | (1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester); (1S-cis)-Abacavir Monophosphate; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Metabolites |
| 杂质: | Abacavir - In House Impurity |
| CAS号: | 136470-77-4 |
| 分子式: | C₁₄H₁₉N₆O₄P |
| 状态： | 白色固体 |
| 熔点： | 189-194°C (dec.) |
| 分子量: | 366.31 |
| 储存： | -20˚C Freezer |
| 溶解性: | Methanol, Water |
| 类别: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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