产品编号：A104997
产品规格：10mg
产品价格：面议
| 标准品编号: | A104997 |
| 名称: | trans-Abacavir-d4 Hydrochloride |
| 别名: | (1R,4R)-rel-4-[2-Amino-6-[cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cyclopentene-1-methanol Hydrochloride; Abacavir Stable Isotope |
| CAS号: | 1346605-40-0 |
| 备用CAS: | 267668-71-3-未标记 |
| 分子式: | C₁₄H₁₅D₄ClN₆O |
| 分子量: | 326.82 |
| 类别: | Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | trans-Abacavir-d4 Hydrochloride is deuterium labeled trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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