N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M; Teriflunomide; Leflunomide EP Impurity B; Aubagio; A1726; (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide; Femorix; HMR 1726; SU 20
杂质:
Leflunomide EP Impurity B
CAS号:
163451-81-8
备用CAS:
108605-62-5 (Unspecified Stereochemistry)p
分子式:
C₁₂H₉F₃N₂O₂
外观:
白色固体
熔点:
229-232°C
分子量:
270.21
储存:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
溶解度:
DMSO, Methanol (Sparingly)
类别:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
A77 1726 (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective thanÂinjectable interferon beta 1a (Rebif®).
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