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产品基本信息
产品编号：T787025
产品名称：N-Trifluoroacetyl Deacetylcolchicine
产品CAS：26195-65-3
规格含量：500mg
产品价格：面议
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产品详细介绍
标准品编号:
T787025
名称:
N-Trifluoroacetyl Deacetylcolchicine
别名:
2,2,2-Trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-Deacetyl-N-(trifluoroacetyl)colchicine; NSC 305987;
CAS号:
26195-65-3
分子式:
C₂₂H₂₂F₃NO₆
外观:
Faintly Yellow Crystalline Powder
分子量:
453.41
储存:
冰箱
溶解度:
Chloromethane, Dichlormethane, DMSO, Methanol
类别:
Standards; Enzyme Activators and Inhibitors;
应用:
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献
Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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