2,3,4,6-Tetra-O-pivaloyl-D-mannopyranosyl fluoride (CAS# 187269-63-2) is a useful chiral building block used for stereospecific α-D-mannosylations. 2,3,4,6-Tetra-O-pivaloyl-D-mannopyranosyl fluoride also appears in the preparation of di- and trivalent phenyl substituted glycosides as selectin inhibitors.