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| 产品基本信息 |
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| 产品编号：A596515 |
| 产品名称：(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride |
| 产品CAS：426226-35-9 |
| 规格含量：10g |
| 产品价格：面议 |
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| 产品详细介绍 |
| 标准品编号: |
A596515 |
| 名称: |
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride |
| 别名: |
Methyl (1R,4S)-4-Aminocyclopent-2-ene-1-carboxylate Hydrochloride |
| CAS号: |
426226-35-9 |
| 备用CAS: |
352226-74-5 |
| 分子式: |
C₇H₁₁NO₂ • HCl |
| 分子量: |
141.173646 |
| 类别: |
Building Blocks; Miscellaneous; |
| 应用: |
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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