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产品编号：T789500
产品名称：N-Trifluoroacetyl-N-methyl-deacetylcolchiceine
产品CAS：1217782-80-3
规格含量：1g
产品价格：面议
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产品详细介绍
标准品编号:
T789500
名称:
N-Trifluoroacetyl-N-methyl-deacetylcolchiceine
别名:
2,2,2-Trifluoro-N-methyl-N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;
CAS号:
1217782-80-3
分子式:
C₂₂H₂₂F₃NO₆
外观:
Yellow Solid
分子量:
453.41
溶解度:
Chloromethane, Dichlormethane, DMSO, Methanol
类别:
Standards; Enzyme Activators and Inhibitors;
应用:
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
参考文献
Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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