2,2,2-Trifluoro-N-[2-(4-iodo-2,5-dimethoxyphenyl)ethyl]acetamide is an intermediate in the synthesis of 2C-TFM Hydrochloride (C830000), a potent agonist of the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C. 2C refers to a series of 2,5-dimethoxyphenethylamines with psychoactive effects.