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产品基本信息
产品编号：N757010
产品名称：(R,S)-Nornicotine-d4
产品CAS：66148-18-3
规格含量：5mg
产品价格：面议
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产品详细介绍
标准品编号:
N757010
名称:
(R,S)-Nornicotine-d4
别名:
3-(2-Pyrrolidinyl)pyridine-d4; (±)-1'-Demethylnicotine-d4; (±)-3-(2-Pyrrolidinyl)pyridine-d4; (±)-1'-Demethylnicotine-d4; (±)-Nornicotine-d4; 2-(3-Pyridinyl)pyrrolidine-d4; 3-(Pyrrolidin-2-yl)pyridine-d4;
CAS号:
66148-18-3
参考CAS号:
5746-86-1-unlabelled
分子式:
C₉H₈D₄N₂
外观:
Colourless to Pale Yellow Oil
分子量:
152.23
储存:
Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度:
Chloroform (Slightly), Methanol (Slightly)
稳定性:
Light Sensitive
类别:
Standards; Chiral Molecules; Isotopic Labeled Analogues; Stimulant; Nicotine Derivatives and Metabolites;
应用:
Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity.
参考文献
Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),
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