3-Phenylbenzylamine is used as a reagent for the preparation of N-bis[3-(2-arylethynyl)benzyl]-N'-isopropylureas. Based on biological studies, N-bis[3-(2-arylethynyl)benzyl]-N'-isopropylureas is considered a potent and selective microsomal prostaglandin E synthase (mPGES-1) inhibitors.