(4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4- (4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; NK 104-d5; NK 104-d5 (lactone); Nisvastatin-d5; P 872441-d5;
参考CAS号:
141750-63-2-unlabelled
分子式:
C₂₅H₁₇D₅FNO₃
外观:
白色至淡黄色固体
熔点:
72-75°C
分子量:
408.48
储存:
Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
溶解度:
Chloroform (Slightly), Ethyl Acetate (Slightly)
类别:
Standards; Chiral Molecules; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
A labelled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells.
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