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PSI-7977-D5
产品基本信息
产品编号:P839643
产品名称:PSI-7977-D5
产品CAS:
规格含量:25mg
产品价格:面议
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产品详细介绍
标准品编号: P839643
名称: PSI-7977-D5
别名: Isopropyl(2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate-D5; N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-1-methylethyl Ester L-Alanine-D5; GS-7977-D5; Sofosbuvir-D5;
参考CAS号: 1190307-88-0 unlabelled
分子式: C₂₂H₂₄D₅FN₃O₉P
外观: 白色至Pale Orange Solid
熔点: >74°C (dec.)
分子量: 534.48
储存: Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度: Chloroform (Slightly), Methanol (Slightly)
类别: Building Blocks; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用: PSI-7977-D5 is the isotope labelled analog of PSI-7977. PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
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