5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1;
CAS号:
4311-88-0
分子式:
C₁₃H₁₃N₃OS
外观:
Yellow Solid
熔点:
153-155°C
分子量:
259.33
储存:
冰箱
溶解度:
DMSO (Slightly), Methanol (Slightly)
种类:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
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