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产品基本信息
产品编号：L465882
产品名称：Linaclotide-d4
产品CAS：
规格含量：5mg
产品价格：面议
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产品详细介绍
标准品编号:
L465882
名称:
Linaclotide-d4
别名:
L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-d4-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); 11: PN: WO2008151257 SEQID: 55 claimed protein-d4; 13: PN: WO2008151257 SEQID: 57 Claimed Protein-d4; 2074: PN: US20090062207 SEQID: 3 Claimed Protein-d4; 40: PN: WO2010065751 SEQID: 55 Claimed Protein-d4; 42: PN: WO2010065751 SEQID: 57 claimed protein-d4; 55: PN: US20100152118 SEQID: 55 Claimed Protein-d4; 55: PN: WO2011069038 SEQID: 55 Claimed Sequence-d4; 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein-d4; 57: PN: WO2011069038 SEQID: 57 Claimed Sequence-d4; 57: PN: WO2012037380 SEQID: 57 Claimed Protein-d4
参考CAS号:
Unlabelled: 851199-59-2
分子式:
C₅₉H₇₅D₄N₁₅O₂₁S₆
外观:
白色至白色固体
熔点:
>222°C (dec.)
分子量:
1530.76
储存:
冰箱
溶解度:
DMSO (Slightly), Water (Slightly)
种类:
Building Blocks; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
参考文献
Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);
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