(S)-N-(1-amino-1-oxopropan-2-yl)-6-((3-(3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamido)benzyl)amino)-1H-indazole-3-carboxamide and other 3-carboxamido-2H-indazole-6-arylamide derivatives have been studied as highly selective CRAF inhibitors.